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Banga, H. S.
- Clinicopathological Studies on Vitamin D3 Toxicity and Therapeutic Evaluation of Aloe vera in Rats
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Authors
Sambhaji G. Chavhan
1,
R. S. Brar
1,
H. S. Banga
1,
H. S. Sandhu
2,
S. Sodhi
1,
P. D. Gadhave
1,
V. R. Kothule
1
Affiliations
1 Departments of Veterinary Pathology, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Departments of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana - 141 004, Punjab, IN
1 Departments of Veterinary Pathology, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Departments of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana - 141 004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 18, No 1 (2011), Pagination: 35-43Abstract
A study was conducted to examine the clinical signs, hematological, biochemical and histopathological changes in vitamin D3 toxicity at a dose rate 2 mg/kg b.wt. of vitamin D3 and to assess the protective effect of Aloe vera in vitamin D3 toxicity. The clinical signs observed were anorexia, progressive weight loss, difficulty in movement and respiration, diarrhea, epistaxis, subnormal body temperature and nervous signs before death. Mortality was observed in treated rats between day 10 and day 19 of treatment. The gross postmortem changes observed were severe emaciation, white chalky deposits on epicardial surface of heart, pin point white deposits on cortical surface of kidneys with pale yellow discoloration and diffused white deposits on serosal surface of stomach and intestine with bloody ingesta in lumen. The hematological changes included non-significant increase in hemoglobin and total leukocyte count and significant increase in relative neutrophil count. The biochemical changes observed were significant increase in plasma concentration of calcium, phosphorus and blood urea nitrogen, whereas a significant decrease in the concentration of albumin and total plasma protein was observed. The histopathological lesions included calcification of various organs, viz., tongue, stomach, intestines, kidney, heart, aorta, larynx, trachea, lungs, spleen, choroid plexus arteries of brain and vas deferens. The Aloe vera juice (2.5% in drinking water) has no protective effect on vitamin D3 toxicity (2 mg/kg b.wt.).Keywords
Aloe vera, calcification, histopathological lesions, hypercalcemia, vitamin D3 toxicity- A Case of Intranasal Hemangioma and Concurrent Tetracycline-induced Ulcerative Gastritis in Dogs
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Authors
Affiliations
1 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab
3 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
1 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab
3 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 1 (2010), Pagination: 33-36Abstract
Incidence of drug-induced gastritis and ulceration in human medicine is well established. Besides, unilateral hemangioma, a unique concurrent case of tetracycline induced gastric toxicity in a dog, characterized by gastritis and ulceration is being reported here. Grossly, the appearance of gastric ulcers mimicked the appearance of Italian pizza. Histological examination further supported drug-induced etiology in this case. This is probably the one of the few cases in the annals of veterinary medicine to be documented as drug-induced gastric toxicity in dog.Keywords
Dogs, doxycycline, gastritis, histopathology, tetracyclines- Neuropathological Studies of Chickens Following Exposure to Chlorpyrifos
Abstract Views :157 |
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Authors
Affiliations
1 Departments of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
2 Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
1 Departments of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
2 Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN